• Ann Pharmacother · Jul 2003

    Intraspinal use of morphine.

    • Kathryn E Gaudette and S Jay Weaver.
    • H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA. katiegaudette@hotmail.com
    • Ann Pharmacother. 2003 Jul 1;37(7-8):1132-5.

    ObjectiveTo compare the different sterility standards and the cost issues involved when choosing an opioid product for intraspinal administration.Data SourcesLiterature accessed through MEDLINE and other Internet search engines (September 2002-April 2003) was evaluated. Key search terms included epidural/intrathecal, opioids, sterility, and compounding.Data SynthesisIntraspinal use is prevalent in the area of pain management. Product selection is of utmost importance when administering through the intraspinal route. An evaluation of guidelines on sterility and a cost comparison were conducted.ConclusionsThe preservative-free commercially available products that are indicated for intrathecal/epidural use are the best alternative due to proper outside testing and stringent quality assurance. The generic morphine preservative-free product may also be considered if proper steps are taken to ensure that the final product is diluted properly.

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