• Maike Vom Hove, Freerk Prenzel, Holm H Uhlig, and Eva Robel-Tillig.
• Pediatric Pneumology and Allergology, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Electronic address: Maike.Hove@medizin.uni-leipzig.de.
• J. Pediatr. 2014 Jan 1;164(1):40-45.e4.

ObjectiveTo assess and compare long-term pulmonary outcomes in former preterm-born, very low birth weight (VLBW) children with and without bronchopulmonary dysplasia (BPD) born in the surfactant era.Study DesignPulmonary function tests (ie, spirometry, body plethysmography, and gas transfer testing) were performed in children with a history of VLBW and BPD (n = 28) and compared with a matched preterm-born VLBW control group (n = 28). Medical history was evaluated by questionnaire.ResultsAt time of follow-up (mean age, 9.5 years), respiratory symptoms (36% vs 8%) and receipt of asthma medication (21% vs 0%) were significantly more frequent in the preterm-born children with previous BPD than in those with no history of BPD. The children with a history of BPD had significantly lower values for forced expiratory volume in 1 second (z-score -1.27 vs -0.4; P = .008), forced vital capacity (z-score -1.39 vs -0.71 z-score; P = .022), and forced expiratory flow rate at 50% of forced vital capacity (z-score -2.21 vs -1.04; P = .048) compared with the preterm control group.ConclusionPreterm-born children with a history of BPD are significantly more likely to have lung function abnormalities, such as airway obstruction and respiratory symptoms, at school age compared with preterm-born children without BPD.Copyright © 2014 Mosby, Inc. All rights reserved.

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