• Anesthesia and analgesia · Nov 1978

    A test of the carcinogenicity of enflurane, isoflurane, halothane, methoxyflurane, and nitrous oxide in mice.

    • E I Eger, A E White, C L Brown, C G Biava, T H Corbett, and W C Stevens.
    • Anesth. Analg. 1978 Nov 1;57(6):678-94.

    AbstractWe exposed Swiss ICR mice for 2-hour periods to 1/32, 1/8 and/or 1/2 MAC enflurane, halothane, isoflurane, methoxyflurane, or N2O both in utero during the last 1/2 of pregnancy (4 exposures at 2-day intervals) and after delivery (24 exposures at 2-to-3-day intervals). Anesthetics were delivered in air or in O2. Thus, 1973 mice were exposed and examined after 15 months of life for the development of neoplastic lesions. Neoplastic lesions (principally pulmonary adenomas, lymphomas, hepatocyte lesions, liver vascular lesions) were found in all treatment and control sets. There was no indication that a specific anesthetic or anesthetic dose was carcinogenic. Our results do not confirm the suggestion that isoflurane is a hepatocarcinogen, nor do our data suggest that the modern inhaled anesthetics pose a significant threat of carcinogenicity.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…