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Current drug targets · Aug 2009
ReviewClinical uses of low-dose ketamine in patients undergoing surgery.
- M Berti, M Baciarello, R Troglio, and G Fanelli.
- Department of Anesthesiology, Critical Care and Pain Medicine, University Hospital of Parma, Parma, Italy. mberti@ao.pr.it
- Curr Drug Targets. 2009 Aug 1;10(8):707-15.
AbstractKetamine acts mainly as a N-methyl-D-aspartate receptor (NMDAr) antagonist. Originally developed as a general anesthetic, it is now seldom employed as such in richer countries due to the relatively high risk of psychotomimetic adverse effects. Recently, low-dose regimens in the range of 0.25-0.5 mg/kg as an initial bolus followed by 50-500 kappag/kg/h have been proposed as an adjuvant for postoperative analgesia and for the reduction of exogenous opioid-induced hyperalgesia. In this review, we examine the evidence for clinical usefulness of perioperative ketamine infusion and its role in the context of general and/or regional anesthesia.
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