• Weiwei Dou, Lixiang Wang, Huiliang Liu, Pengchuan Zhang, Chengcheng Guo, Yahua Liu, Lizhi Ma, Kun Sun, Wenjun Ma, Qian Wang, and Xiaodong Guo.
• Emergency Medical Center, General Hospital of Chinese Armed Police Forces, Beijing 100039, China, Corresponding author: Wang Lixiang, Email: wjjjwlx@163.com.
• Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Oct 1;26(10):718-21.

ObjectiveTo explore the effect of the interrupted abdominal aorta compression after cardiopulmonary resuscitation (IAAC-CPR) on cardiopulmonary cerebral resuscitation in a rabbit model of cardiac arrest (CA).MethodsAccording to the random number table, 10 New Zealand rabbits of both genders were equally divided into the chest compression-cardiopulmonary resuscitation (CC-CPR) group or IAAC-CPR group, with 5 rabbits in each group. CA model was reproduced by injection of iced-potassium chloride into the jugular vein and obstruction of trachea to produce asphyxia. CA was maintained for 3 minutes before cardiopulmonary resuscitation(CPR). CC-CPR was performed with assisted ventilation + chest compression, while IAAC-CPR was performed by the way of assisted ventilation + chest compressions + compressions on abdominal aorta. The hemodynamics and cerebral cortex blood flow were observed during resuscitation. Time of return of spontaneous circulation (ROSC), 24-hour survival rates, and scores of neurological function, and situation of abdominal organs were recorded.ResultsAt 30, 60, 90 and 120 seconds after CPR, the cerebral blood flow (CBF, PU value) and mean arterial pressure (MAP, mmHg, 1 mmHg=0.133 kPa) of IAAC-CPR group were significantly higher than those of CC-CPR group (CBF 30 seconds: 16.1 ± 6.0 vs. 7.8 ± 2.2, 60 seconds: 91.6 ± 11.8 vs. 57.3 ± 23.2, 90 seconds: 259.9 ± 74.9 vs. 163.6 ± 50.3, 120 seconds: 301.5 ± 60.5 vs. 208.4 ± 23.8; MAP 30 seconds: 46.4 ± 9.4 vs. 31.4 ± 8.7, 60 seconds: 55.8 ± 13.8 vs. 34.0 ± 11.5, 90 seconds: 61.2 ± 11.5 vs. 38.2 ± 10.1, 120 seconds: 63.6 ± 11.8 vs. 40.2 ± 10.2, all P<0.05). Compared with CC-CPR group, in IAAC - CPR group, the time necessary for ROSC was obviously shortened (seconds: 182.0 ± 59.0 vs. 312.6 ± 86.6, t=2.787, P=0.024), 24-hour nerve function score was significantly lowered (2.4 ± 1.7 vs. 4.6 ± 0.6, t = 2.974, P = 0.023). The successful recovery rate (80.0% vs. 60.0%, χ² = 0.000, P=1.000) and 24-hour survival rate (80.0% vs. 40.0%, χ² = 0.417, P=0.519) were significantly increased, but without statistical significance. No liver damage was found at 24 hours after ROSC.ConclusionsIn the early recovery of CA in rabbit, IAAC-CPR can result in better cerebral blood flow perfusion as compared with CC-CPR, and it significantly reduced damage to the nervous system function without producing abdominal organ damage.

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