• F Conreux, O Best, M P Preckel, C Lhopitault, L Beydon, F Pouplard, and J C Granry.
• Département d'anesthésie-réanimation, CHU Angers, 49033 Angers, France.
• Ann Fr Anesth Reanim. 2001 May 1;20(5):438-45.

ObjectiveTo study electroencephalographic (EEG) changes in children during induction of anaesthesia with 8% sevoflurane.PatientsTwenty patients were consecutively included (ASA I-II; aged: 13-101 months).Material And MethodProspective study; approved by the Ethics Committee; written informed consent obtained from parents; anaesthesia induced with 8% sevoflurane in oxygen; no premedication was given; to collect the EEG data, non-invasive electodes were installed before induction; EEG was recorded continuously and stored on a computer for later analyses (descriptive analysis).ResultsMyoclonics movements were observed during induction of anaesthesia in two boys. Myoclonics movements stopped spontaneously without therapy. Epileptiform EEG activity (spikes and poly-spikes, burst suppression) was observed. In the 18 others cases, during sevoflurane induction, EEG changed rapidly with an increase in the range of beta activity (> 13 Hz) (n = 15) and in slow (< 8 Hz) and delta activity (< 4 Hz). In 14 patients, at time of laryngoscopy, the EEGs showed monophasic slow data activity (sharp high-voltage slow waves). Periods of EEG isoelectrical (burst suppression) were seen without spikes in four cases.ConclusionAt 2 MAC, epileptiform EEG activity has been observed during sevoflurane anaesthesia. In a short group of patients, this raises the question of avoiding sevoflurane in patients who have a history of epilepsy.

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