• Hai Cun Shi, Jian Guo Zhong, Ping Lei Pan, Pei Rong Xiao, Yuan Shen, Li Juan Wu, Hua Liang Li, Yuan Ying Song, Gui Xiang He, and Hong Ye Li.
• Department of Neurology, Yancheng Third People's Hospital, The affiliated Yancheng hospital of Southeast University medical college, YanCheng, 224001 Jiangsu Province, People's Republic of China. yc3yhcshi@gmail.com
• Neurol. Sci. 2013 Jul 1;34(7):1049-55.

AbstractVoxel-based morphometry (VBM) studies have provided cumulative evidence of gray matter (GM) atrophy in patients with progressive supranuclear palsy (PSP) relative to healthy controls (HC). However, not all findings have been entirely concordant. Herein, we performed a quantitative meta-analysis study in order to consistently quantify GM anomalies in PSP. We conducted a systematic search for VBM studies of PSP patients and HC using PubMed and Embase databases from January 2000 to May 2012. Meta-analysis of these VBM studies was performed using a newly improved voxel-based meta-analytic technique, effect-size signed differential mapping. A total of 9 cross-sectional VBM studies that involved 143 PSP patients and 216 HC subjects met the inclusion criteria. Considerable regional GM volume decrease was detected in the thalamus, basal ganglia, midbrain, insular cortex, and frontal cortex. These findings remained largely unchanged following jackknife sensitivity analyses. The present meta-analysis provided evidence of PSP-specific GM atrophy. This finding might help contribute to our understanding of the neurobiological basis underlying PSP.

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