• Dietmar Fries, Petra Innerhofer, Peter Perger, Manfred Gütl, Sabine Heil, Nikolaus Hofmann, Werner Kneifel, Ludwig Neuner, Thomas Pernerstorfer, Georg Pfanner, Herbert Schöchl, Bernhard Ziegler, Camillo Kölblinger, and Sibylle Kozek-Langenecker.
• Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin, Medizinische Universität Innsbruck, Osterreich.
• Anasthesiol Intensivmed Notfallmed Schmerzther. 2010 Sep 1;45(9):552-61.

AbstractEven nowadays and at specialized centers, one of the leading causes of death is exsanguination. Trauma-induced coagulopathy (TIC) occuring with massive blood loss primarily results from loss of coagualtion factors and platelets and is aggravated by hemodilution. In addition, hyperfibrinolysis, hypothermia, acidosis and hypocalcaemia also contribute to the development of severe haemostatic derangement. During the past few years new insights into the pathophysiology of TIC and the widespread use of viscoelastic coagulation monitoring provoked the development of alternative treatment concepts. As for the previously recommended standard therapy using fresh frozen plasma and platelet concentrates also for alternative strategies no data from large prospective randomized studies are available until now, however, the evidence is growing favoring the use of coagulation factor concentrates guided by viscoelastic measurements.© Georg Thieme Verlag Stuttgart · New York.

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