• L Cole, R Bellomo, D Journois, P Davenport, I Baldwin, and P Tipping.
• Department of Intensive Care, Austin & Repatriation Medical Centre, Melbourne, Australia.
• Intensive Care Med. 2001 Jun 1;27(6):978-86.

ObjectiveTo evaluate whether high volume haemofiltration improves haemodynamics and affects serum cytokine and complement concentrations in human septic shock.Design And SettingRandomized cross-over clinical trial in a tertiary intensive care unit.PatientsEleven patients with septic shock and multi-organ failure.InterventionsPatients were assigned to either 8 h of high-volume haemofiltration (HVHF; 6 l/h) or 8 h of standard continuous veno-venous haemofiltration (CVVH; 1 l/h) in random order.Measurements And Main ResultsWe measured changes in haemodynamic variables, dose of norepinephrine required to maintain a mean arterial pressure greater than 70 mmHg and plasma concentrations of complement anaphylatoxins and several cytokines. An 8-h period of HVHF was associated with a greater reduction in norepinephrine requirements than a similar period of CVVH (median reduction: 10.5 vs. 1.0 microg/min; p = 0.01; median percentage reduction: 68 vs. 7%; p = 0.02). Both therapies were associated with a temporary reduction (p < 0.01) in the plasma concentration of C3a, C5a, and interleukin 10 within 2 h of initiation. HVHF was associated with a greater reduction in the area under the curve for C3a and C5a (p < 0.01). The concentration of the measured soluble mediators in the ultrafiltrate was negligible.ConclusionsHVHF decreases vasopressor requirements in human septic shock and affects anaphylatoxin levels differently than standard CVVH.

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