• J Trauma Acute Care Surg · May 2012

    Comparative Study

    Recombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis.

    • Yoshihito Ogawa, Kazuma Yamakawa, Hiroshi Ogura, Takeyuki Kiguchi, Tomoyoshi Mohri, Yasushi Nakamori, Yasuyuki Kuwagata, Takeshi Shimazu, Toshimitsu Hamasaki, and Satoshi Fujimi.
    • Department of Emergency and Critical Care, Osaka General Medical Center, Osaka, Japan. yoshi.ogawa@hp-emerg.med.osaka-u.ac.jp
    • J Trauma Acute Care Surg. 2012 May 1;72(5):1150-7.

    BackgroundRespiratory dysfunction associated with severe sepsis is a serious condition leading to poor prognosis. Activation of coagulation is a consequence of and contributor to ongoing lung injury in severe sepsis. The purpose of this study was to examine the efficacy of recombinant human soluble thrombomodulin (rhTM), a novel anticoagulant agent, for treating patients with sepsis-induced disseminated intravascular coagulation (DIC) in terms of mortality and respiratory dysfunction.MethodsThis study comprised 86 consecutive patients with sepsis-induced DIC who required ventilator management. The initial 45 patients were treated without rhTM (control group), and the following 41 patients were given rhTM (0.06 mg/kg/d) for 6 days (rhTM group). Patients were followed up for 90 days after study entry. Sequential Organ Failure Assessment (SOFA) score and lung injury score were recorded until 7 days after entry.ResultsThe baseline characteristic of severity of illness was significantly higher in the rhTM group than in the control group. Nevertheless, 90-day mortality rate in the rhTM group was significantly lower than that in the control group (37% vs. 58%, p = 0.038). There was a significant difference in the serial change of SOFA score from baseline to day 7 between the two groups (p = 0.009). Both the respiratory component of the SOFA score and the lung injury score in the rhTM group were significantly lower compared with the control group (p = 0.034 and p < 0.001, respectively).ConclusionsrhTM may have a significant beneficial effect on mortality and respiratory dysfunction in patients with sepsis-induced DIC.Level Of EvidenceIII, therapeutic study.

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