• M Plit, R Pearson, A Havryk, J Da Costa, C Chang, and A R Glanville.
• Department of Thoracic Medicine, St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia. mplit@stvincents.com.au
• Intern Med J. 2012 Apr 1;42(4):434-8.

BackgroundEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an accurate and minimally invasive technique that has been shown to have excellent diagnostic yield in the investigation of mediastinal and hilar lymphadenopathy. There is, however, little evidence comparing this procedure to the traditional diagnostic approach of transbronchial lung (TBLB) and endobronchial (EB) biopsies combined with characteristic clinical and radiological features in sarcoidosis.AimTo compare the diagnostic yield of EBUS-TBNA, TBLB and EB in patients with suspected sarcoidosis.MethodsData from 40 consecutive patients with suspected sarcoidosis who underwent combined EBUS-TBNA with TBLB and EB biopsies were recorded.ResultsA total of 37 patients was confirmed as sarcoidosis, and three had other diagnoses. There was no difference in diagnostic accuracy rates between EBUS-TBNA and TBLB for all stages of sarcoidosis (84% vs 78%, P= 0.77). Combined EBUS-TBNA and TBLB procedures yielded a diagnostic accuracy of 100%. There was a highly significant difference in diagnostic accuracy between EBUS-TBNA and EB in stage I (80% vs 27%) (P < 0.01) and stage II disease (86% vs 27%) (P < 0.01). Similarly, a highly significant difference in diagnostic accuracy was seen between TBLB and EB (P < 0.01). No adverse events occurred.ConclusionEndobronchial ultrasound-guided transbronchial needle aspiration alone has a high diagnostic yield with a very low complication rate for patients with suspected sarcoidosis.© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.

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