• J Clin Anesth · Aug 2000

    Clinical Trial

    Tropisetron in the prevention of postoperative nausea and vomiting.

    • J G Boogaerts, F M Bardiau, L Seidel, A Albert, and B E Ickx.
    • Department of Anesthesiology, University Hospital Center, Charleroi and Erasme Hospital, Brussels, Belgium. dr.boogaerts@belgacom.be
    • J Clin Anesth. 2000 Aug 1;12(5):402-8.

    Study ObjectivesTo evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures.DesignProspective, open, nonrandomized, observational, interventional study.SettingPostanesthesia care unit, and surgical wards of the University Hospital Center, Charleroi.PatientsA total of 1,132 elective surgical inpatients (>15 years of age) in two separate surveys. The first prospective survey covered all surgical adult inpatients (n = 671) after various surgical procedures over a 3-month period. A new 3-month survey was performed to assess the effectiveness of the preventive measure and included another 461 patients.InterventionsRisk factors associated with nausea and vomiting were recorded in the first survey and used to establish an antiemetic policy. This consisted in the administration of tropisetron 2 mg intravenously after anesthesia induction, if two patient-related risk factors associated with high-risk surgery and general anesthesia were present.Measurements And Main ResultsNausea frequency and intensity, assessed every 4 hours using a visual analog scale (VAS), frequency and times of vomiting episodes and the need for rescue medication were recorded for 72 hours postoperatively. Nausea was experienced by 18.8% and vomiting by 9.8% of the patients in the first survey (211 high risk-patients of 671). In the second survey, 137 patients of 461, considered at high-risk received prophylactic tropisetron. The proportion of patients having nausea decreased to 11.1% (p,178 0.01) and vomiting episodes to 2.8% (p < 0.001). Twenty-six of the tropisetron-treated patients (19%) suffered subsequent postoperative nausea and vomiting (PONV). Patient satisfaction with tropisetron was high.ConclusionProphylactic tropisetron can reduce the incidence of PONV in selected high-risk inpatients undergoing various types of surgical procedures.

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