• J. Toxicol. Clin. Toxicol. · Jan 1998

    Case Reports

    ECG conduction delays associated with massive bupropion overdose.

    • P A Paris and J R Saucier.
    • Department of Emergency Medicine, Maine Medical Center, Portland 04102, USA. parisp@mail.mmc.org
    • J. Toxicol. Clin. Toxicol. 1998 Jan 1;36(6):595-8.

    BackgroundBupropion, a relatively new antidepressant, is highly regarded for its safety profile in therapeutic doses and in the overdose. Seizure is the primary adverse reaction associated with bupropion overdoses. Clinically significant cardiovascular complications are rare.Case ReportWe report the case of an adult male who ingested 9 g bupropion and developed neurologic toxicity as well as intraventricular conduction disturbances on electrocardiogram. Cardiac monitoring of these patients should be considered.

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