• Neuroscience letters · Feb 2014

    Increased precuneus connectivity during propofol sedation.

    • Xiaolin Liu, Shi-Jiang Li, and Anthony G Hudetz.
    • Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
    • Neurosci. Lett. 2014 Feb 21;561:18-23.

    AbstractUsing functional magnetic resonance imaging in human participants, we show that sedation by propofol to the point of lost overt responsiveness during the performance of an auditory verbal memory task unexpectedly increases functional connectivity of the precuneus with cortical regions, particularly the dorsal prefrontal and visual cortices. After recovery of consciousness, functional connectivity returns to a pattern similar to that observed during the wakeful baseline. In the context of a recent proposal that highlights the uncoupling of consciousness, connectedness, and responsiveness in general anesthesia, the increased precuneus functional connectivity under propofol sedation may reflect disconnected endogenous mentation or dreaming that continues at a reduced level of metabolic activity.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

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