Neuroscience letters
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Neuroscience letters · Feb 2014
New therapeutic uses for an alpha2 adrenergic receptor agonist--dexmedetomidine in pain management.
Dexmedetomidine was initially approved for clinical use as a sedative. Its development in pain management has been limited. Dexmedetomidine has analgesic effects and analgesic-sparing properties, especially for patients with obstructed airways. ⋯ Dexmedetomidine has potential adverse effects such as hypotension and bradycardia. Therefore, dexmedetomidine is contraindicated for patients suffering from bradycardia or using β-adrenergic antagonists. Clinical trials of dexmedetomidine in chronic pain or hyperalgesia are lack.
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Neuroscience letters · Feb 2014
Application of intermittent galvanic vestibular stimulation reveals age-related constraints in the multisensory reweighting of posture.
In this study we examined the effects of intermittent short-duration Galvanic Vestibular Stimulation (GVS) during a multisensory perturbation of posture in young and elderly adults. Twelve young (24.91±6.44 years) and eleven elderly (74.8±6.42 years) participants stood upright under two task conditions: (a) quiet standing and (b) standing while receiving pseudo-randomly presented bipolar 2 s GVS pulses. ⋯ Intermittent GVS decreased the excessive postural sway induced by the concurrent visual and proprioceptive perturbation in young but not in elderly participants. It is suggested that GVS increases sensory reliance on the vestibular system while elderly adults are less able to exploit this stimulation in order to reduce the destabilizing effect of the multisensory perturbation on their posture.
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Using functional magnetic resonance imaging in human participants, we show that sedation by propofol to the point of lost overt responsiveness during the performance of an auditory verbal memory task unexpectedly increases functional connectivity of the precuneus with cortical regions, particularly the dorsal prefrontal and visual cortices. After recovery of consciousness, functional connectivity returns to a pattern similar to that observed during the wakeful baseline. In the context of a recent proposal that highlights the uncoupling of consciousness, connectedness, and responsiveness in general anesthesia, the increased precuneus functional connectivity under propofol sedation may reflect disconnected endogenous mentation or dreaming that continues at a reduced level of metabolic activity.
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Neuroscience letters · Feb 2014
Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states.
Melatonin (MLT) is a neurohormone implicated in several physiological processes such as sleep. Contrasting results have been produced on whether or not it may act as a hypnotic agent, and the neurobiological mechanism through which it controls the vigilance states has not yet been elucidated. In this study we investigated the effect of MLT (40 mg/kg), a non-selective MT1/MT2 receptor agonist (UCM793, 40 mg/kg), and a selective MT2 partial agonist (UCM924, 40 mg/kg) on the 24-h vigilance states. ⋯ Moreover, it raised the number of REMS episodes (+57%) but did not affect REMS duration. Taken together, these findings show that MLT and non-selective MT1/MT2 receptor agonists do not increase the quantity of sleep but differently influence the three vigilance states. In addition, they support the evidence that selective MT2 receptor agonists increase NREMS duration compared to MLT and non-selective MT1/MT2 agonists.
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Neuroscience letters · Feb 2014
Neocortical integration of transplanted GABA progenitor cells from wild type and GABA(B) receptor knockout mouse donors.
Most cortical interneurons originate in a region of the embryonic subpallium called the medial ganglionic eminence (MGE). When MGE cells are transplanted into cerebral cortex, these progenitors migrate extensively and differentiate into functional inhibitory neurons. Although MGE progenitors have therapeutic potential following transplantation, it is unknown precisely how these cells distribute within neocortical lamina of the recipient brain. ⋯ MGE-derived neurons from WT and GABA(B1)R KO mice preferentially and densely distributed in neocortical layers 2/3, 5 and 6. As expected, MGE-derived neurons differentiated into parvalbumin+ and somatostatin+ interneurons within these neocortical lamina. Our findings provide insights into the anatomical integration of MGE-derived interneurons following transplantation.