• David N Moskovitz and Young-In Kim.
• Department of Medicine, Division of Gastroenterology, University of Toronto, St. Michael's Hospital, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.
• Nutr. Rev. 2004 Nov 1;62(11):443-7.

AbstractPerioperative immune modulation using specialized enteral diets containing specific immunonutrients may improve postoperative outcomes in critically ill patients compared with standard formulas. A study from Italy involving 305 patents with histologically confirmed cancer of the gastrointestinal tract undergoing major elective surgery and preoperative weight loss < 10% demonstrated that a specialized preoperative oral formula enriched with arginine, omega-3 fatty acids, and RNA for 5 days before surgery with no nutritional support postoperatively (preoperative group) was as effective as pre- and postoperative administration of the same enriched formula (perioperative group) in decreasing the incidence of postoperative infections and length of hospital stay. Both pre- and perioperative immunonutritional strategies were superior to the conventional approach (no artificial nutrition perioperatively).

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