• Young Wan Kim, Soo-Ki Kim, Cheol Su Kim, Ik Yong Kim, Mee Yon Cho, and Nam Kyu Kim.
• Department of Surgery, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
• Anticancer Res. 2014 Jul 1;34(7):3481-7.

BackgroundWe examined cytokine profiles and evaluated the association between cytokine levels, pathological stages, and neutrophil/lymphocyte ratio (NLR).Materials And MethodsPatients with colorectal cancer (n=20, TNM stage I, II, and III) were enrolled. Levels of nine cytokines [interleukin (IL)-4,-6, -8, -10, -12, tumor necrosis factor-alpha (TNF-α), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF)] were measured in serum, normal mucosa, and tumor using the Bio-Plex® cytokine assay.ResultsThe mean IL8, GM-CSF and VEGF levels were higher in tumors, whereas the mean IL6 level was higher in serum. Cytokine levels correlated with TNM stage (IL6 and IL8 in serum, and IL8 and VEGF in tumor) and with NLR (IL6 and IL8 in serum, and IL8 in tumor).ConclusionDifferent cytokine profiles were observed in serum, normal mucosa, and tumor tissue. The elevation of specific cytokines in sera or tumors reflects features of advanced disease.Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

31 keywords...

hide…