• Maria Sanfilippo, Francesco Alessandri, Ahmed Abdelgawwad Wefki Abdelgawwad Shousha, Antonio Sabba, and Alessandra Cutolo.
• Department of Anesthesiology and Intensive Care, Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.
• Anesthesiol Res Pract. 2013 Jan 1;2013:389782.

AbstractBackground. The obese patients have differences in body composition, drug distribution, and metabolism. Sugammadex at T 2 recovery in a dose of 2 mg kg(-1) of real body weight (RBW) can completely reverse the NMB block; in our study we investigated the safety and efficacy of Sugammadex dose based on their ideal body weight (IBW). Methods. 40 patients of both sexes undergoing laparoscopic bariatric surgery were enrolled divided into 2 groups according to the dose of Sugammadex: the first received a dose of 2 mg kg(-1) of IBW and the second received a dose of 2 mg kg(-1) of RBW. Both were anesthetized with doses calculated according to the IBW: fentanyl 2  μ g kg(-1), propofol 3 mg kg(-1), rocuronium 0,6 mg kg(-1), oxygen, air, and desflurane (6-8%). Maintenance doses of rocuronium were 1/4 of the intubation dose. Sugammadex was administrated at T 2 recovery. Results. The durations of intubation and maintenance doses of rocuronium were similar in both groups. In IBW group, the T 4/T 1 value of 0.9 was reached in 151 ± 44 seconds and in 121 ± 55 seconds in RBW group (P = 0.07). Discussion. Recovery times to T 4/T 1 of 0.9 are surprisingly similar in both groups without observing any postoperative residual curarization. Conclusion. Sugammadex doses calculated according to the IBW are certainly safe for a rapid recovery and absence of PORC.

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