• E Mark Haacke, Beena G Sood, Zahid Latif, Robert J Galli, Charles W Dunlap, and Matthew J Gelmini.
• Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA. bsood@med.wayne.edu
• Resp Care. 2012 Nov 1;57(11):1901-7.

BackgroundWe have previously demonstrated aerosol delivery during conventional and high frequency oscillatory (HFOV) ventilation using magnetic resonance imaging (MRI) in piglets. There are no reports on aerosol delivery during high frequency jet ventilation (HFJV).ObjectiveTo compare delivery of aerosolized gadopentetate dimeglumine (Gd-DTPA) in 3 neonatal ventilator circuits: conventional mechanical ventilation, HFOV, and HFJV.MethodsAerosols of Gd-DTPA (0.025 mol/L) generated using a jet nebulizer placed in the inspiratory limb of each ventilator were delivered into an in vitro lung model simultaneously. Multi-slice T1-weighted spin-echo sequence scans were obtained prior to and after 10 and 20 min of cumulative aerosol delivery. Gd-DTPA concentration was calculated from signal intensity changes, and the total amount of Gd-DTPA was estimated.ResultsGd-DTPA was visualized in the lung model at 10 and 20 min for all 3 ventilators. Gd-DTPA delivery was highest with conventional mechanical ventilation (1.92 μmol at 10 min, 2.89 μmol at 20 min), followed by HFJV (1.59 μmol at 10 min, 1.98 μmol at 20 min) and HFOV (0.79 μmol at 10 min, 1.00 μmol at 20 min).ConclusionsThis is the first report of effective aerosol delivery in a neonatal HFJV circuit. Future studies are needed for more accurate quantification of aerosol deposition.

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