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- K T Park, C Nespor, and J Kerner.
- Department of Pediatric Gastroenterology, Stanford University Medical Center, Lucile Packard Children's Hospital, 750 Welch Road, Palo Alto, CA 94304, USA.
- J Perinatol. 2011 Apr 1;31 Suppl 1:S57-60.
AbstractParenteral nutrition (PN), containing fat emulsions derived from soybean, has been implicated in the progression of PN-associated liver disease and cholestasis, particularly in infants with short bowel syndrome. Clinical use of Omegaven, a parenteral fish-oil emulsion, has been shown in recent studies to be a promising therapy to reverse liver disease and cholestasis. This review summarizes the rationale, relevant clinical investigations and future direction of Omegaven therapy for PN-dependent infants.
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