• Y Fujii, Y Saitoh, H Tanaka, and H Toyooka.
• Department of Anesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.
• J Clin Anesth. 1999 Mar 1;11(2):108-12.

Study ObjectivesTo evaluate the efficacy and safety of granisetron-droperidol combination for the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery.DesignProspective, randomized, double-blind study.SettingUniversity hospital.Patients150 ASA physical status I patients (108 females, 42 males) scheduled for elective middle ear surgery.InterventionsPatients received granisetron 40 micrograms/kg (n = 50), droperidol 20 micrograms/kg (n = 50), or granisetron 40 micrograms/kg plus droperidol 20 micrograms/kg (n = 50) intravenously immediately before induction of anesthesia.Measurements And Main ResultsA standard general anesthetic technique and postoperative analgesia were used throughout the study. A complete response, defined as no PONV and no need for another rescue antiemetic, from 0 to 3 hours after anesthesia occurred in 78%, 56%, and 94% of patients who had received granisetron, droperidol, and granisetron plus droperidol, respectively. The corresponding incidence between 3 and 24 hours after anesthesia was 80%, 52% and 94%. Thus, a complete response within the first 24-hour postanesthetic period was greater in patients receiving granisetron-droperidol combination than in those receiving granisetron alone or droperidol alone (p < 0.05). No clinically adverse events were observed in any of the groups.ConclusionsA combination of granisetron and droperidol is more effective than droperidol or granisetron alone for the prevention of PONV after middle ear surgery.

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