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Randomized Controlled Trial Clinical Trial
Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients.
- Akira Kudoh, Hiroshi Katagai, and Tomoko Takazawa.
- Department of Anesthesiology, Hirosaki National Hospital, Japan.
- J Clin Anesth. 2002 Mar 1;14(2):107-10.
Study ObjectiveTo investigate whether total IV anesthesia with ketamine, propofol, and fentanyl affects the frequency of postoperative psychosis emergence or confusion in schizophrenic patients.DesignProspective, controlled study.SettingHirosaki National Hospital and Hakodate Watanabe Hospital.Patients76 ASA physical status I and II schizophrenic patients taking chronic antipsychotic drugs and schedule for orthopedic surgery of extremities.InterventionsIn Group A (n = 38) patients, anesthesia was maintained with sevoflurane, nitrous oxide, and fentanyl. In Group B (n = 38) patients, anesthesia was maintained with ketamine, propofol, and fentanyl.Measurements And Main ResultsThe frequency of psychosis emergence or confusion (54%) in Group A during the first 48 hours after surgery was significantly higher than the 30% figure in Group B.ConclusionKetamine, when combined with propofol and fentanyl, is an appropriate anesthetic drug for schizophrenic patients.
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