• Ann Pharmacother · Sep 1992

    Case Reports

    Hypersensitivity and anaphylactoid reactions to ciprofloxacin.

    • R L Deamer, J G Prichard, and G J Loman.
    • Ventura County Medical Center, Office of Medical Education, CA 93003.
    • Ann Pharmacother. 1992 Sep 1;26(9):1081-4.

    ObjectiveTo report three cases of life-threatening hypersensitivity reactions to the oral administration of ciprofloxacin.Case SummaryLife-threatening hypersensitivity reactions to oral ciprofloxacin, characterized by diffuse, erythematous, nonpruritic, blanching rash, with fever and hypotension, occurred in two HIV-infected patients. One of these reactions was considered anaphylactoid. A similar hypersensitivity reaction was documented in a non-HIV-infected patient.DiscussionPremarketing clinical trials described no reports of life-threatening anaphylactoid hypersensitivity reactions to ciprofloxacin. However, postmarketing surveillance studies have documented their occurrence. Seven cases of anaphylactoid reaction to ciprofloxacin have now been documented in HIV-infected patients.ConclusionsAs with trimethoprim/sulfamethoxazole, HIV-infected people treated with ciprofloxacin may be at special risk for hypersensitivity reactions.

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