• Transl Res · Jan 2015

    Review

    Epigenetic regulation of persistent pain.

    • Guang Bai, Ke Ren, and Ronald Dubner.
    • Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD. Electronic address: baigliangy@hotmail.com.
    • Transl Res. 2015 Jan 1; 165 (1): 177199177-99.

    AbstractPersistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.Copyright © 2015 Elsevier Inc. All rights reserved.

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