• Shahab Razavi, Scott A Weinstein, David J Bates, Sam Alfred, and Julian White.
• Toxinology Department, Women's & Children's Hospital, North Adelaide, SA 5006, Australia; Medical School, University of Bristol, Bristol BS8 1TH, UK.
• Toxicon. 2014 Jul 1;85:17-26.

BackgroundThe mulga snake (Pseudechis australis) is the largest terrestrial venomous snake in Australia. It is capable of inflicting severe and occasionally fatal envenoming, but there have been few studies of P. australis bites.ObjectivesTo highlight and reinforce the main features of P. australis envenoming and to provide a clearer picture of the epidemiology of bites from this species.MethodsSelected case records kept by the Toxinology Dept. (Women's and Children's Hospital, Adelaide, Australia) were reviewed retrospectively to determine definite P. australis bites.Inclusion Criteriadefinite cases where the snake was identified by a competent person and/or lab specimens (bite site/urine) tested positive for "black snake" using CSL snake venom detection kit in a locality within the known range of P. australis, but without sympatry with other Pseudechis spp.Exclusion Criteriawhere the snake could not be clearly identified under criteria above. Epidemiological and clinical information was recorded and analysed for the definite cases.ResultsA total of 27 cases were identified as definite P. australis bites; there were no fatalities. The median age was 35.5 years (IQR 51-23) and 80% of bites occurred in males. More bites occurred in the warmer months (Dec-March) and in those handling/interfering with snakes. Seven people were bitten whilst asleep at night. 21/27 patients developed systemic envenoming (based on signs, symptoms and laboratory results) and 17 cases received antivenom. Local bite site pain (18) and swelling (17) were common as were non-specific generalised symptoms such as nausea, vomiting and headache. Myotoxicity (11) and anticoagulant coagulopathy (10) occurred frequently; haemolysis was seen in fewer cases (3). Two patients developed local tissue injury around the bite site requiring further treatment.ConclusionsThis study confirms previous reports about P. australis bites with respect to high rates of envenoming, commonly associated with pain and swelling and systemic effects of rhabdomyolysis and anticoagulant coagulopathy. Systemic envenoming, even severe cases, responds well to antivenom therapy. Compared to other Australian snakes, a high proportion of bites occur in people asleep at night. Medically significant local tissue injury around the bite site may occur and may be associated with inappropriate first-aid, particularly the vascular occlusive type.Copyright © 2014 Elsevier Ltd. All rights reserved.

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