• E Arroyo Úcar, A Dominguez-Rodriguez, and P Abreu-Gonzalez.
• Servicio de Cardiología, Hospital Universitario de Canarias, Tenerife, España.
• Med Intensiva. 2012 Jan 1;36(1):11-4.

ObjectiveTo evaluate whether the size of acute myocardial infarction (AMI) shows circadian variability.DesignAn observational, prospective study.SettingA 12-bed coronary care unit.PatientsConsecutive patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.InterventionsThe patients were divided into two groups according to the time of onset of AMI symptoms (Group A: 0-12hours, Group B: 12-24hours).Main Variables Of InterestAge, sex, cardiovascular risk factors, coronary anatomy, left ventricular ejection fraction, infarct location, time from onset of symptoms to reperfusion, presence of heart failure upon admission, and peak troponin I value.ResultsA total of 108 patients with a diagnosis of STEMI were included. Patients in group A showed a higher troponin I concentration compared to group B (troponin I: 70.85±16.38 versus 60.90±22.92ng / ml, p=0.003). In the multivariate analysis the onset of AMI between 0-12hours was identified as an independent predictor of infarct size (OR: 1.133, 95%CI 1.012-1.267, p=0.01).ConclusionsAn onset of AMI between 0-12hours results in a significantly larger final size of necrosis compared with any other time of presentation.Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.

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