• Injury · Aug 2012

    The effectiveness of hypertonic saline and pentoxifylline (HTS-PTX) resuscitation in haemorrhagic shock and sepsis tissue injury: comparison with LR, HES, and LR-PTX treatments.

    • Ho Jung Kim and Kang Hyun Lee.
    • Department of Emergency Medicine, College of medicine, Bucheon Hospital of Soonchunhyang University, South Korea. lovelydr@schbc.ac.kr
    • Injury. 2012 Aug 1;43(8):1271-6.

    PurposeTo compare lung and liver injury and laboratory results in haemorrhagic shock and sepsis models treated with combinations of lactated Ringer's solution (LR), 7.5% hypertonic saline (HTS), hydroxyethyl starch (HES), and pentoxifylline (PTX).MethodsMale Sprague-Dawley rats (200-290 g) were assigned randomly to one of four treatment groups (n=16 per group): (1) LR; (2) HES; (3) LR-PTX; and (4) HTS-PTX. Each group was subdivided into (1) haemorrhagic shock (n=8) and (2) sepsis (n=8) model groups. A venous catheter was used to inject resuscitation fluids, and an arterial catheter was used to withdraw blood and monitor mean arterial pressure (MAP). Lung and liver histology, bronchoalveolar lavage (BAL) fluid, and cytokine levels were evaluated.ResultsThe mean lung injury score was 1.7. At 24h after treatment, the total leucocyte count in the BAL fluid was significantly (p<0.05) higher with LR treatment (10 × 10(6) ± 0.8) than with other treatments in the sepsis model groups (HES, 6 × 10(6) ± 1.2; LR-PTX, 5 × 10(6) ± 1.5; HTS-PTX, 5 × 10(6) ± 0.6). The higher total leucocyte count after LR treatment was attributable to a greater increase in the number of neutrophils (17 ± 1.5%) compared with increases after the other treatments (HES, 6 ± 0.8%; LR-PTX, 10 ± 1.3%; HTS-PTX, 5 ± 0.4%). In the sepsis model groups, the total hepatic injury score was also significantly (p<0.05) higher with LR treatment (9.9 ± 0.5) than with the other treatments (HES, 6.7 ± 0.8; LR-PTX, 5.6 ± 0.7; HTS-PTX, 3.1 ± 0.9). This also occurred in the shock model (LR, 10.6 ± 2.1; HES, 5.8 ± 0.9; LR-PTX, 7.3 ± 0.9; HTS-PTX, 3.5 ± 0.9). As compared with LR treatment, HTS-PTX resuscitation resulted in a 49% decrease in TNF-α, 29% decrease in IL-1β, and 58% decrease in IL-6 in the shock model at 24h (p<0.05), and the respective decreases were 45, 24, and 35% in the sepsis model (p<0.05).ConclusionHTS-PTX was superior to HES, LR-PTX, and LR for treating shock and sepsis, and LR-PTX and HES gave better results than LR therapy alone.Copyright © 2012 Elsevier Ltd. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…