• Lorraine A Fitzpatrick, Christine E Dabrowski, Gregory Cicconetti, David N Gordon, Socrates Papapoulos, Henry G Bone, and John P Bilezikian.
• GlaxoSmithKline, Biopharm Development Unit, 709 Swedeland Road, UM2291, King of Prussia, Pennsylvania 19406, USA. lorraine.a.fitzpatrick@gsk.com
• J. Clin. Endocrinol. Metab. 2011 Aug 1;96(8):2441-9.

ContextRonacaleret, a calcium-sensing receptor antagonist that stimulates PTH release from the parathyroid glands, was evaluated as an oral osteoanabolic agent for the treatment of osteoporosis.ObjectiveOur objective was to compare the effects of ronacaleret, teriparatide, and alendronate on bone mineral density (BMD) and markers of bone turnover.Design And SettingIn this randomized, placebo-controlled, dose-ranging trial, spine and hip BMD were assessed by dual-energy x-ray absorptiometry and bone turnover markers were measured.PatientsPatients included 569 postmenopausal women with low BMD.InterventionsSubjects were offered open-label 20 μg teriparatide sc once daily or were randomized to 100, 200, 300, or 400 mg oral ronacaleret once daily, 70 mg alendronate once weekly, or placebo and were followed for up to 12 months.Main Outcome MeasurePercentage change from baseline in lumbar spine BMD was assessed at month 12.ResultsWith ronacaleret, the increases in lumbar spine BMD at 12 months (0.3-1.6%) were significantly lower than those attained with teriparatide (9.1%) or alendronate (4.5%). There were small decreases in total hip, femoral neck, and trochanter BMD at month 12 with ronacaleret compared with increases in the teriparatide and alendronate arms. Bone turnover markers increased in the ronacaleret and teriparatide arms and decreased in the alendronate arm. PTH elevations with ronacaleret were prolonged relative to those previously reported with teriparatide.ConclusionThe densitometric findings in the context of prolonged PTH elevation and increased bone turnover suggest ronacaleret induces mild hyperparathyroidism. Ronacaleret only modestly increased lumbar spine BMD and decreased BMD at hip sites.

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