• Fransien M Struik, Marieke L Duiverman, Petra M Meijer, Jellie A Nieuwenhuis, Huib Am Kerstjens, and Peter J Wijkstra.
• Department of Pulmonary Diseases and Home Mechanical Ventilation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. f.m.struik@umcg.nl
• Resp Care. 2011 Oct 1;56(10):1522-5.

BackgroundLong-term noninvasive ventilation (NIV) is an effective treatment for patients with chronic respiratory failure due to chest-wall deformity, but it is unknown if the time required for the patient to adjust to long-term NIV depends on whether the NIV is volume-targeted or pressure-targeted.ObjectiveTo determine whether volume controlled or pressure controlled NIV is easier to implement in patients with chronic respiratory failure due to chest-wall deformity.MethodsWe randomized 16 ventilator-naïve patients to receive either volume-targeted or pressure-targeted nocturnal NIV. The primary outcome was the number of days needed to successfully establish NIV, defined as adequate adjustment and effective ventilation, as measured with overnight arterial blood gas measurement.ResultsTwo patients did not tolerate volume NIV, and switched to pressure NIV. NIV was successfully established in both groups after a median 6.0 days. There were no significant differences between the groups at any time point in P(aCO(2)) or P(aO(2)) improvement, nor in changes over time.ConclusionsThere was no significant difference in days needed to successfully establish volume NIV versus pressure NIV in patients with chest-wall deformity. However, two patients switched successfully from volume NIV to pressure NIV, which suggests that they preferred pressure NIV.

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