• Mora Murri, Regina García-Delgado, José Alcázar-Ramírez, Ana Fernández-Ramos, Juan Alcaide, Fernando Cardona, and Francisco J Tinahones.
• Servicio de Hematología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. moramurri@gmail.com
• Resp Care. 2011 Nov 1; 56 (11): 1830-6.

BackgroundThe sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells.ObjectiveTo evaluate whether one month of CPAP treatment affects circulating-progenitor-cell levels and oxidative stress in patients with sleep apnea-hypopnea syndrome.MethodsWe enrolled 13 patients with sleep apnea-hypopnea syndrome who required nasal CPAP. We evaluated white-blood-cell oxidative stress and CD45-, CD34+, KDR+, and CD133+ cell levels via flow-cytometry, before and one month after CPAP treatment.ResultsSuperoxide anion and hydrogen peroxide were reduced, and markers of protection against oxidative stress were increased after CPAP. Progenitor-cell levels increased significantly after CPAP. There was a significant negative correlation between CD45-, CD34+, KDR+, and CD133+ cell levels and the severity of sleep apnea-hypopnea syndrome and superoxide anion.ConclusionsCD45-, CD34+, KDR+, and CD133+ cell levels rose significantly and reached values close to those in the control group after one month of CPAP. This change was accompanied by a significant decrease in oxidative stress, and no change in anthropometric or metabolic variables, including insulin resistance, weight, blood pressure, or lipid levels; consequently, the increase in progenitor-cell levels might be attributable to reduced oxidative stress.

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