• Tsukasa Nakamura, Yasuhiro Kawagoe, Tsukasa Suzuki, Hisataka Shoji, Yoshihiko Ueda, and Hikaru Koide.
• Department of Medicine, Shinmatsudo Central General Hospital, Chiba, Japan.
• Am. J. Med. Sci. 2007 Oct 1;334(4):244-7.

BackgroundDirect hemoperfusion with the polymyxin B-immobilized fiber (PMX-20R) column has a positive effect on outcome in patients with sepsis or septic shock. The PMX-05R column has a low priming volume and has been used in pediatric patients with septic shock. The aim of the present study was to determine whether PMX-F treatment with the PMX-05R column is effective in elderly patients with septic shock.Patients And MethodsWe performed direct hemoperfusion twice with the PMX-05R column in 8 septic shock patients who were over 80 years of age. Five of the 8 patients survived. The 3 patients who died were undergoing hemodialysis for chronic renal failure, and methicillin-resistant Staphylococcus aureus was detected in all 3.ResultsPMX-F treatment significantly increased systolic and diastolic blood pressures (P = 0.0004 for both) and significantly reduced heart rate (P < 0.0001), the blood endotoxin level (P = 0.0011), blood IL-6 level (P = 0.039), C-reactive protein level (P < 0.0001), and white blood cell count (P < 0.0001).ConclusionsDirect hemoperfusion with the PMX-05R column is effective in ameliorating clinical and laboratory abnormalities in elderly septic shock patients.

36 keywords...

hide…