GnRH-analogues have a longer half-life and stronger receptor affinity than native GnRH. They block the secretion of gonadotropins from the anterior pituitary, producing a hypoestrogenic state. Preoperative treatment with GnRH-agonists for 3 months prior to hysterectomy reduces the size of uterine fibroids by about 50%. ⋯ Other results are: a smaller peroperative blood loss, a shorter hospitalization time, and a tendency to easier operations. Side effects are predominantly hypoestrogenic. Treatment with GnRH-agonists before hysterectomy is recommended in cases of large fibroids, when technical problems may be anticipated, when preoperative anemia is present, or when it is desirable to postpone surgery.
Department of Obstetrics & Gynaecology, University Hospital, Malmö, Sweden.
Acta Obstet Gynecol Scand Suppl. 1997 Jan 1;164:94-7.
AbstractGnRH-analogues have a longer half-life and stronger receptor affinity than native GnRH. They block the secretion of gonadotropins from the anterior pituitary, producing a hypoestrogenic state. Preoperative treatment with GnRH-agonists for 3 months prior to hysterectomy reduces the size of uterine fibroids by about 50%. The hematologic profile is improved and subjective symptoms reduced. Other results are: a smaller peroperative blood loss, a shorter hospitalization time, and a tendency to easier operations. Side effects are predominantly hypoestrogenic. Treatment with GnRH-agonists before hysterectomy is recommended in cases of large fibroids, when technical problems may be anticipated, when preoperative anemia is present, or when it is desirable to postpone surgery.