Acta obstetricia et gynecologica Scandinavica. Supplement
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Acta Obstet Gynecol Scand Suppl · Jan 1997
Treatment of uterine fibroids with GnRH-analogues prior to hysterectomy.
GnRH-analogues have a longer half-life and stronger receptor affinity than native GnRH. They block the secretion of gonadotropins from the anterior pituitary, producing a hypoestrogenic state. Preoperative treatment with GnRH-agonists for 3 months prior to hysterectomy reduces the size of uterine fibroids by about 50%. ⋯ Other results are: a smaller peroperative blood loss, a shorter hospitalization time, and a tendency to easier operations. Side effects are predominantly hypoestrogenic. Treatment with GnRH-agonists before hysterectomy is recommended in cases of large fibroids, when technical problems may be anticipated, when preoperative anemia is present, or when it is desirable to postpone surgery.
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Acta Obstet Gynecol Scand Suppl · Jan 1986
Randomized Controlled Trial Comparative Study Clinical TrialCyproterone acetate versus levonorgestrel combined with ethinyl estradiol in the treatment of acne. Results of a multicenter study.
In spite of an abundant literature on antiandrogen treatment with cyproterone acetate (CA) there have been no objectively measured results to prove statistically the possible superiority of CA over combined oral contraceptive pills in the treatment of acne vulgaris. A multicenter study was therefore done, in which two preparations containing CA in combination with ethinylestradiol (EE) were compared with a marketed combined oral contraceptive pill. The preparations studied were: CA 2 mg + EE 50 micrograms (Diane), CA 2 mg + EE 35 micrograms (Diane mite), Levonorgestrel 150 micrograms + EE 30 micrograms (Neovletta). ⋯ The groups thus constituted were of similar size and comparable with regard to age, degree of acne, and menstrual and contraceptive histories. As the number of acne lesions varied considerably between patients all data were converted into percentage change during treatment before they were processed in a computer. After only 4 months of treatment the patients on Diane and Diane mite had a significantly greater reduction in the number of acne lesions compared with those on Neovletta.(ABSTRACT TRUNCATED AT 250 WORDS)
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Acta Obstet Gynecol Scand Suppl · Jan 1984
Case Reports Comparative StudyGeneral anaesthesia versus epidural block for caesarean section in patient with pre-eclampsia.
To protect mother and fetus from the stress of vaginal delivery, caesarean section is to be chosen in severe cases of pre-eclampsia. When general anaesthesia is used, attention must be paid to the increase in arterial pressure, pulmonary arterial pressure (PA) and pulmonary capillary wedge pressure (PCW), which occur during intubation, tracheal suction and extubation. In epidural block, on the other hand, hypotension is a common phenomenon if the hypovolaemia is not corrected before the anaesthesia. It is important for the anaesthesiologist to see these women early to be able to treat the hypovolaemia and hypertension prior to caesarean section.
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Acta Obstet Gynecol Scand Suppl · Jan 1984
Causes and consequences of maternal and fetal sympathoadrenal activation during parturition.
The sympathoadrenal system is activated in both the mother and fetus during parturition. The fetal plasma catecholamines may reach extremely high levels during deliveries complicated by asphyxia. ⋯ Such an increase may be avoided by adequate maternal pain relief and by the sympathetic blockade which follows epidural anaesthesia. Fetal sympathoadrenal activation during parturition seems on the contrary to be of positive functional importance both for fetal circulatory regulation in utero a well as for the neonatal adaptation in terms of pulmonary function and metabolic stimulation.
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Acta Obstet Gynecol Scand Suppl · Jan 1980
Randomized Controlled Trial Comparative Study Clinical TrialA comparative study of uterine activity and fetal heart rate pattern in labor induced with oral prostaglandin E2 or oxytocin.
Labor was induced for medical reasons at or near term in altogether 200 patients. The women were randomly assigned to low amniotomy and either oral PGE2 or intravenous infusion of oxytocin. The initial PGE2 dose was 0.5 mg, followed by 1.0 mg every hour for up to 24 hours. ⋯ One period of hypertonus was observed in one patient treated with PGE2 but it was not associated with alterations in FHR and disappeared without additional therapy. Both mild and more severe variations in FHR occurred but were equally common on both treatment groups. There was no perinatal mortality among the newborns and the Apgar score 5 minutes after delivery was 8 or more.