Acta obstetricia et gynecologica Scandinavica. Supplement
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Acta Obstet Gynecol Scand Suppl · Jan 1980
Randomized Controlled Trial Comparative Study Clinical TrialA comparative study of uterine activity and fetal heart rate pattern in labor induced with oral prostaglandin E2 or oxytocin.
Labor was induced for medical reasons at or near term in altogether 200 patients. The women were randomly assigned to low amniotomy and either oral PGE2 or intravenous infusion of oxytocin. The initial PGE2 dose was 0.5 mg, followed by 1.0 mg every hour for up to 24 hours. ⋯ One period of hypertonus was observed in one patient treated with PGE2 but it was not associated with alterations in FHR and disappeared without additional therapy. Both mild and more severe variations in FHR occurred but were equally common on both treatment groups. There was no perinatal mortality among the newborns and the Apgar score 5 minutes after delivery was 8 or more.