• J. Toxicol. Clin. Toxicol. · Jan 2003

    Case Reports

    Cardiotoxicity associated with intentional ziprasidone and bupropion overdose.

    • Abhik K Biswas, Luke A Zabrocki, Kendra L Mayes, and Cynthia L Morris-Kukoski.
    • Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA. akbiswas@mar.med.navy.mil
    • J. Toxicol. Clin. Toxicol. 2003 Jan 1;41(1):79-82.

    BackgroundZiprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.Case ReportA 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.ConclusionsWe present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.

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