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J. Toxicol. Clin. Toxicol. · Jan 2003
Case ReportsCardiotoxicity associated with intentional ziprasidone and bupropion overdose.
- Abhik K Biswas, Luke A Zabrocki, Kendra L Mayes, and Cynthia L Morris-Kukoski.
- Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA. akbiswas@mar.med.navy.mil
- J. Toxicol. Clin. Toxicol. 2003 Jan 1;41(2):101-4.
BackgroundZiprasidone and bupropion are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supratherapeutic doses, but recently the Federal Drug Administration has issued a caution regarding ziprasidone use in combination with other drugs that are known to prolong the QTc interval.Case ReportA 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours postingestion.ConclusionsWe present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
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