• M L Mingus, A K Shamsi, J F Recant, and J B Eisenkraft.
• Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York, USA.
• J Clin Anesth. 1996 May 1;8(3):220-4.

Study ObjectiveTo determine the effect of propofol without succinylcholine on intubating conditions and postoperative myalgias in ambulatory surgical patients undergoing general anesthesia.DesignProspective, double-blind, randomized study.SettingAmbulatory surgery adult patients.Patients56 ASA physical status I and II adult patients undergoing general endotracheal anesthesia.InterventionsGroup 1 patients received thiamylal plus succinylcholine, Group 2 patients received propofol plus succinylcholine; and Group 3 patients received propofol plus saline. All patients received fentanyl, lidocaine, and nitrous oxide plus isoflurane in oxygen.Measurements And Main ResultsIncidence and severity of fasciculations, tracheal intubating conditions, and myalgias on the first and third postoperative days were measured. Propofol did not affect the incidence or severity of fasciculations following succinylcholine, or the incidence of myalgias. Of patients who received propofol without succinylcholine, intubation was successful in 85%.ConclusionsPropofol did not affect the incidence or severity of postoperative myalgias following succinylcholine.

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