• Rajiv Gandhi, David Santone, Mark Takahashi, Omar Dessouki, and Nizar N Mahomed.
• Division of Orthopaedic Surgery, University Health Network, University of Toronto, Toronto ON, Canada. Rajiv.gandhi@uhn.on.ca
• Knee. 2013 Oct 1;20(5):316-8.

IntroductionThe prevalence of unrelieved pain following total knee arthroplasty (TKA) is substantial.ObjectiveWe asked if cytokine markers of inflammation in preoperative serum or knee synovial fluid (SF) would predict pain 2 years following TKA.MethodsDemographic data and functional outcomes were recorded at baseline and 2 years with the WOMAC index. Serum and SF tissue samples were collected at the time of surgery. Linear regression modeling was used to determine the relationship between SF/serum inflammatory markers and a lesser improvement in self reported pain at two years follow-up.ResultsOf our 28 patient cohort, significant correlations between serum and SF levels were found for IL-1β (p<0.002), MIP-1β (p<0.001), adiponectin (p<0.001) and leptin (p<0.001). Adjusted analysis showed that greater SF concentrations of TNF-α, MMP-13 and IL-6 were independent predictors of less pain improvement at two years follow-up (p<0.05).ConclusionsThose patients, having ongoing pain despite no clinical or radiological cause, may have an inflammatory profile characterizing a predisposition to ongoing pain after TKA.Level Of EvidencePrognosis study, Level 2.Copyright © 2012 Elsevier B.V. All rights reserved.

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