• H Muñoz Letelier, A González Arellano, J Dagnino Sepúlveda, and J González Sotomayor.
• Departamento de Anestesiología, Escuela de Medicina, Universidad Católica de Chile, Santiago, Chile. hmunoz@med.puc.cl
• Rev Esp Anestesiol Reanim. 1999 Jun 1;46(6):252-5.

HypothesisDifferences in the hemodynamic effects of induction agents may cause them to affect the onset of action of rocuronium differently.ObjectivesTo compare the onset of action of rocuronium after induction with etomidate and thiopental.Patients And MethodsForty adult ASA I patients received 3 micrograms.kg-1. Three minutes later anesthesia was induced randomly with either 5 mg.kg-1 of thiopental (group I, n = 20) or 0.3 mg.kg-1 of etomidate (group II, n = 20). Rocuronium 0.6 mg.kg-1 was administered over 5 s. Baseline blood pressure and heart rate were measured just before delivery of rocuronium and just before intubation. Onset of action was defined as the time from injection of rocuronium until achievement of a blockade > or = 95% of the first electromyographic response in a trian-of-four stimulus of the short adductor of the thumb. We also studied intubation conditions.ResultsEtomidate was associated with a smaller decrease in systolic arterial pressure than was thiopental. Onset of action was 81 +/- 29 s in group I versus 72 +/- 23 s in group II (NS). Similar intubation conditions were observed in both groups.ConclusionsThese results suggest that the induction drug does not affect rocuronium's onset of action.

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