• Hip Int · May 2014

    Effect of a selective COX-2 inhibitor, celecoxib, on heterotopic ossification after total hip arthroplasty: a case-controlled study.

    • Julius K Oni, Joseph R Pinero, Bryan M Saltzman, and Fredrick F Jaffe.
    • 1 Department of Orthopaedic Surgery, Einstein Medical Center, Philadelphia - USA.
    • Hip Int. 2014 May 1;24(3):256-62.

    AbstractHeterotopic ossification (HO) is a well-known complication of total hip arthroplasty (THA), especially when the direct lateral approach is used. In this study, we examined the effect of the selective COX-2 inhibitor, celecoxib, on the rates of HO after THA. A control group consisting of 108 patients that did not receive celecoxib was compared with a study group consisting of 106 patients that did receive celecoxib. We assessed the presence and grade of HO using the Brooker classification and Harris hip scores were determined pre- and postoperatively to better quantify clinical outcomes. In this retrospective study of prospectively collected data, celecoxib is associated with a significant reduction in the incidence of HO in patients undergoing THA.

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