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Nihon Shokakibyo Gakkai Zasshi · Aug 2014
Case Reports[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia].
- Yasuhiro Iizuka, Hideki Sakai, Konomi Kobayashi, Kazue Iizuka, Eri Ito, Nahoko Mochizuki, Yasuhiro Asahina, and Mamoru Watanabe.
- Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital.
- Nihon Shokakibyo Gakkai Zasshi. 2014 Aug 1;111(8):1618-23.
AbstractA 64-year-old woman was prescribed lamivudine and adefovir (ADV) for chronic hepatitis B. Although her serum creatinine level was normal (<1.01 mg/dl), she developed bone pain due to Fanconi syndrome and osteomalacia. Therefore, ADV was discontinued and she was switched to entecavir (ETV); however, she developed an ETV-resistant mutant virus and a small dose of ADV was restarted. Her hepatitis B virus (HBV) -DNA levels and renal function were closely monitored. She has had preserved creatinine levels and tubular function, with almost undetectable HBV-DNA levels for more than a year after treatment.
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