• David V Schacht, Ken Yamaguchi, Jessica Lai, Kirti Kulkarni, Charlene A Sennett, and Hiroyuki Abe.
• 1 Department of Radiology, Section of Breast Imaging, The University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.
• AJR Am J Roentgenol. 2014 Feb 1;202(2):289-92.

ObjectiveThe purposes of this study were to assess the importance of a personal history of breast cancer as a risk factor for patients referred for screening breast MRI and to evaluate the importance of this risk factor compared with family history.Materials And MethodsA retrospective review of screening breast MRI performed from 2004 to 2012 included a total of 702 patients, 465 of whom had undergone annual MRI and 237 of whom had undergone MRI every 6 months as part of a research protocol.ResultsOf the patients screened, 208 had a personal history of breast cancer, and 345 had a family history as the sole risk factor. An additional 97 patients had both risk factors. The absolute risk for detection of breast cancer at screening MRI among patients with a personal history of cancer was 2.8% (95% CI, 0.6-5.2%). The absolute risk for patients with a strong family history of cancer was 2.0% (95% CI, 0.5-3.5%). The relative risk for detection of breast cancer given a personal history was 1.42 (95% CI, 0.48-4.17) compared with family history. The relative risk when both risk factors were present compared with having only a family history was 3.04 (95% CI, 1.05-8.86).ConclusionA personal history of breast cancer is an important risk factor for the development of subsequent breast cancer. Given the results, consideration should be given to MRI screening of patients with a personal history of breast cancer.

16 keywords...

hide…