-
Acta Anaesthesiol Scand · Mar 1997
Case Reports Clinical Trial Controlled Clinical TrialOral ketamine therapy in the treatment of postamputation stump pain.
- L Nikolajsen, P O Hansen, and T S Jensen.
- Department of Neurology, Aarhus University Hospital, Denmark.
- Acta Anaesthesiol Scand. 1997 Mar 1;41(3):427-9.
BackgroundHyperactivity of N-methyl-D-aspartate (NMDA) receptors may be one of the factors in the maintenance of postamputation stump pain.Case ReportKetamine-a clinical available NMDA receptor antagonist-was administered intravenously to a patient with established stump pain in a double-blind saline-controlled fashion. Following infusion stump pain was alleviated for 31 hours. Ketamine reduced the allodynic area and wind-up-like pain and increased pressure-pain thresholds. Treatment was started with ketamine 50 mg x 4 per day dissolved in juice. No side effects or development of tolerance were observed during a 3-month treatment period.ConclusionNMDA receptor antagonists may have a potential in the treatment of neuropathic pain, including stump pain.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..