Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Mar 1997
Randomized Controlled Trial Comparative Study Clinical TrialRecovery and outcome after propofol and isoflurane anesthesia in patients undergoing laparoscopic hysterectomy.
Laparoscopic hysterectomy (LH) is expected to provide fast and comfortable recovery, plus an early return to normal daily activities. This study was carried out to compare the outcome after LH in patients anesthetized with isoflurane or propofol. ⋯ It is concluded that both isoflurane and propofol are suitable anesthetics for LH. In this study recovery was not fast enough to make the patients suitable for same-day surgery.
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Acta Anaesthesiol Scand · Mar 1997
Case ReportsFour years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia.
N-methyl-D-aspartate (NMDA) receptors are involved in the development of neuropathic pain. Ketamine, a non-competitive NMDA receptor antagonist, has in several case reports given pain relief but efficacy in dosages tolerated in long-term ketamine treatment is unknown. Another substance with an antagonist action at NMDA receptors and which is approved for peroral administration is dextromethorphan. ⋯ We report a patient with severe post-herpetic pain resistant to conventional pain treatment which was treated with ketamine for 4 years with good pain relief. The practical application of long-term treatment in different administration forms of ketamine is described. The patient also responded with pain relief in a double-blind trial with oral dextromethorphan.
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Acta Anaesthesiol Scand · Mar 1997
Randomized Controlled Trial Clinical TrialIntravenous regional analgesia using morphine. The effect on postoperative pain following total knee arthroplasty.
We hypothesised that any peripheral action of morphine may contribute to improved postoperative analgesia. The aim of this study was to evaluate the analgesic efficacy of morphine administered preoperatively into an exsanguinated limb prior to total knee arthroplasty. ⋯ Intravenous regional analgesia using morphine provides no analgesic advantage over the intramuscular route from 6-24 h postoperatively.
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Acta Anaesthesiol Scand · Mar 1997
Case Reports Clinical Trial Controlled Clinical TrialOral ketamine therapy in the treatment of postamputation stump pain.
Hyperactivity of N-methyl-D-aspartate (NMDA) receptors may be one of the factors in the maintenance of postamputation stump pain. ⋯ NMDA receptor antagonists may have a potential in the treatment of neuropathic pain, including stump pain.