• Tiberiu Ezri, Samuel Lurie, Arnold Stein, Shmuel Evron, and Daniel Geva.
• Department of Anesthesiology, Edith Wolfson Medical Center, Holon, Israel.
• J Clin Anesth. 2002 Jun 1;14(4):262-6.

Study ObjectiveTo evaluate the incidence and severity of postoperative nausea and vomiting in women receiving postoperative intravenous morphine or meperidine following gynecologic surgery.DesignProspective, double-blind, randomized study.SettingTertiary-care academic medical center.Patients200 ASA physical status I, II, and III patients scheduled for elective gynecologic surgery.InterventionsPatients received either postoperative IV morphine (n = 100) or meperidine (n = 100) following gynecologic surgery.MeasurementsWe compared pain scores, sedation scores, nausea scores, well-being scores, vomiting rate, and patient satisfaction in both groups 15, 30, 60, and 120 minutes after arrival in the postoperative anesthesia care unit.Main ResultsThe vomiting rate was 8/100 versus 7/100 (at 15 min), 4/100 versus 26/100 (at 30 min) (p < 0.05), 3/100 versus 23/100 (at 60 min) (p < 0.05), and 0/100 versus 0/100 (at 120 min) in the morphine or meperidine groups, respectively. The pain and sedation scores were similar in both groups. No major complications were noted in either group.ConclusionOur study demonstrates an advantage of the use of morphine rather than meperidine for pain control in the immediate postoperative period following gynecologic surgery.

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