• Transfus Apher Sci · Dec 2013

    Case Reports

    The ability of endotoxin adsorption during a longer duration of direct hemoperfusion with a polymyxin B-immobilized fiber column in patients with septic shock.

    • Tomoharu Shimizu, Toru Obata, Hiromichi Sonoda, Hiroya Akabori, Takahisa Tabata, Yutaka Eguchi, Yoshihiro Endo, and Tohru Tani.
    • Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address: tomoharu@belle.shiga-med.ac.jp.
    • Transfus Apher Sci. 2013 Dec 1;49(3):499-503.

    AbstractThe patients' hemodynamic conditions of septic shock due to intra-abdominal infection were improved by the longer duration of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX), reducing plasma endotoxins measured by the novel endotoxin detection method, named endotoxin scattering photometry (ESP) method; however, turbidimetric method could not detect endotoxins. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX. ESP method may more sensitively detect endotoxins than the ordinary turbidimetric method. Moreover, we demonstrated the ability of endotoxin adsorption in spite of the longer duration of PMX.Copyright © 2013 Elsevier Ltd. All rights reserved.

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