• Preventive medicine · Jan 1991

    Planning the analysis of a breast cancer prevention trial.

    • T E Moon.
    • Department of Family and Community Medicine, Arizona Cancer Center, University of Arizona, Tucson 85724.
    • Prev Med. 1991 Jan 1;20(1):109-18.

    AbstractThe analysis of cancer prevention trials necessitates specialized procedures. Differences in the analysis plan between cancer prevention and therapy trials are emphasized. Discussion is focused upon (a) how trial conduct influences the analysis, (b) how noncompliance affects the analysis and the considerations this raises during the design and conduct of the trial, (c) how delays in the effect of the intervention impinges upon the analysis, and (d) statistical methods available to carry out the analysis. The analysis of a cancer prevention trial represents a final step in the evaluation of the study intervention and requires an adaptive planning procedure.

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