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- B N Queenan, K J Lee, H Tan, R L Huganir, S Vicini, and D T S Pak.
- Department of Pharmacology & Physiology, Georgetown University Medical Center, Washington, DC, United States; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
- Neuroscience. 2016 Feb 19; 315: 206-16.
AbstractWhen chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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