• Neuroscience · Feb 2016

    Species differences in behavior and cell proliferation/survival in the adult brains of female meadow and prairie voles.

    • Y Pan, Y Liu, C Lieberwirth, Z Zhang, and Z Wang.
    • Program in Molecular and Translational Medicine, School of Medicine, Huzhou University, Huzhou 313000, PR China; State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, PR China; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.
    • Neuroscience. 2016 Feb 19; 315: 259-70.

    AbstractMicrotine rodents display diverse patterns of social organization and behaviors, and thus provide a useful model for studying the effects of the social environment on physiology and behavior. The current study compared the species differences and the effects of oxytocin (OT) on anxiety-like, social affiliation, and social recognition behaviors in female meadow voles (Microtus pennsylvanicus) and prairie voles (Microtus ochrogaster). Furthermore, cell proliferation and survival in the brains of adult female meadow and prairie voles were compared. We found that female meadow voles displayed a higher level of anxiety-like behavior but lower levels of social affiliation and social recognition compared to female prairie voles. In addition, meadow voles showed lower levels of cell proliferation (measured by Ki67 staining) and cell survival (measured by BrdU staining) in the ventromedial hypothalamus (VMH) and amygdala (AMY), but not the dentate gyrus of the hippocampus (DG), than prairie voles. Interestingly, the numbers of new cells in the VMH and AMY, but not DG, also correlated with anxiety-like, social affiliation, and social recognition behaviors in a brain region-specific manner. Finally, central OT treatment (200 ng/kg, icv) did not lead to changes in behavior or cell proliferation/survival in the brain. Together, these data indicate a potential role of cell proliferation/survival in selected brain areas on different behaviors between vole species with distinct life strategies.Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

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