• Am. J. Obstet. Gynecol. · Jan 2011

    Prognostic analysis of ovarian cancer associated with endometriosis.

    • Sanjeev Kumar, Adnan Munkarah, Haitham Arabi, Sudeshna Bandyopadhyay, Assaad Semaan, Kinda Hayek, Gunjal Garg, Robert Morris, and Rouba Ali-Fehmi.
    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
    • Am. J. Obstet. Gynecol. 2011 Jan 1;204(1):63.e1-7.

    ObjectiveThe objective of the study was to evaluate the prognosis of ovarian cancer arising in endometriosis.Study DesignWe retrospectively compared 42 cases of endometriosis-associated ovarian cancer (EAOC) with 184 cases of ovarian carcinoma without endometriosis (OC).ResultsThe median age in the EAOC group was 52 vs 59 years in OC (P < .05). In comparison with OC, the EAOC patients were more likely to have low-grade (21% vs 8%; P = .04) and early-stage tumors (International Federation of Gynecology and Obstetrics I and II combined) (49% vs 24%; P = .002). Clear cell (21% vs 2%) and endometrioid (14% vs 3%) tumors were more frequent in EAOC, whereas mucinous tumors were more prevalent in OC (P = .001). The median survival (199 vs 62 months) and the 5 year survival (62% vs 51%) were better for EAOC when compared with OC (P = .038). After controlling for age, stage, grade, and treatment, association with endometriosis was not an independent predictor of better survival in ovarian cancer.ConclusionAs such, EAOC has a much better survival rate than OC. This could be explained by the higher prevalence of early-stage and low-grade tumors in EAOC when compared with OC.Copyright © 2011 Mosby, Inc. All rights reserved.

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